SPI 112 |
| رقم الكتالوجGC46011 |
SPI 112 هو مثبط SHP2 (PTPN11) قوي وانتقائي وتنافسي مع IC50s من 1 ميكرومتر و 18.3 ميكرومتر و 14.5 ميكرومتر لـ SHP2 وبروتين فوسفاتيز التيروزين (PTP) و PTP1B ، على التوالي.
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Cas No.: 1051387-90-6
Sample solution is provided at 25 µL, 10mM.
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SPI 112 is cell-impermeable inhibitor of Src homology region 2 domain-containing phosphatase 2 (SHP-2) in cell-free assays (IC50 = 1 μM).1 It selectively inhibits SHP-2 over SHP-1 and protein tyrosine phosphatase 1B (PTP1B; IC50s = 18.3 and 14.5 μM, respectively).
|1. Lawrence, H.R., Pireddu, R., Chen, L., et al. Inhibitors of Src homology-2 domain containing protein tyrosine phosphatase-2 (Shp2) based on oxindole scaffolds. J. Med. Chem. 51(16), 4548-4956 (2008).
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