SRI-43265 (compound 40) is an inhibitor of human antigen R protein (HuR) dimerization, and HuR multimers have been implicated in cancer and inflammatory pathogenesis.
References:
[1]. Preparation of imidazopyridazinamines as RNA-binding protein multimerization inhibitors and methods of use thereof. World Intellectual Property Organization, WO2021216757 A1 2021-10-28.