T 3364366 |
| رقم الكتالوجGC50341 |
T 3364366 هو مثبط ثينوبيريميدينون دلتا 5 ديساتوراز (D5D) عكسي ، بطيء الارتباط ، مع IC50s 1.9 نانومتر و 2.1 نانومتر في خلايا HepG2 و RLN-10 ، على التوالي.
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Cas No.: 1356354-09-0
Sample solution is provided at 25 µL, 10mM.
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Potent and reversible fatty acid desaturase 1 (FADS1; Δ5 desaturase) inhibitor (IC50 values are 1.9 nM and 2.1 nM in human and rat hepatocyte cell lines, respectively). Exhibits >300 fold selectivity for FADS1 over FADS2 (Δ6 desaturase). Inhibits arachidonic acid production in rat and human hepatocyte cell lines. Orally bioavailable.
Miyahisa et al (2016) T-3364366 targets the desaturase domain of delta-5 desaturase with nanomolar potency and a multihour residence time. ACS Med.Chem.Lett. 7 868 PMID:27660693
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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