TAN 452 |
| رقم الكتالوجGC50558 |
TAN 452 عبارة عن مناهض لمستقبلات أفيونية المفعول (DOR) النشط عن طريق الفم والانتقائي المحيطي مع Ki من 0.47 نانومتر و Kb من 0.21 نانومتر.
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Cas No.: 892039-23-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective peripherally acting δ opioid antagonist; Ki values are 0.47, 5.31 and 36.56 nM at hDOR, hKOR, and hMOR, respectively. Kb values are 0.21, 7.18 and 9.43 nM, respectively. Attenuates morphine-induced side effects in vivo. Antianalgesic.
Lattanzi et al (2018) In vitro and in vivo pharmacological activities of 14-O-phenylpropyloxymorphone, a potent mixed mu/delta/kappa-opioid receptor agonist with reduced constipation in mice. Front.Pharmacol. 9 10.3389/fphar.2018.0 PMID:30233377
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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