TAT (47-57), TAMRA-labeled acetate is a fluorescently labeled cell-penetrating peptide derived from the HIV-1 transactivator of transcription (TAT). TAT (47-57), TAMRA-labeled acetate is conjugated to the red fluorescent dye carboxytetramethylrhodamine (TAMRA, with an absorption/emission wavelength of approximately 541/568 nM). TAT (47-57), TAMRA-labeled acetate can be used in studies related to cellular uptake, translocation and drug delivery [1].
In Vitro, The fluorescence signal of TAT (47-57), TAMRA-labeled acetate originates from TAMRA, while TAT provides cell-penetrating ability.
References:
[1]. Yesylevskyy S, et al. Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers. Biophysical journal. 2009 Jul 08;97(1):40-9.
In Vitro, The fluorescence signal of TAT (47-57), TAMRA-labeled acetate originates from TAMRA, while TAT provides cell-penetrating ability.
References:
[1]. Yesylevskyy S, et al. Alternative mechanisms for the interaction of the cell-penetrating peptides penetratin and the TAT peptide with lipid bilayers. Biophysical journal. 2009 Jul 08;97(1):40-9.