Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60). Tat-IKIP (46-60) is a IκB kinase ( IKK ) -targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS -induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis [1] [2].
References:
[1]. Liu H, et al. A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. J Immunol. 2021 Sep 15;207(6):1652-1661.
[2]. Gao, C.J, et al. IKK beta-targeting short peptides and application thereof in inflammatory diseases. 2020-11-24.
References:
[1]. Liu H, et al. A Peptide Derived from IKK-Interacting Protein Attenuates NF-κB Activation and Inflammation. J Immunol. 2021 Sep 15;207(6):1652-1661.
[2]. Gao, C.J, et al. IKK beta-targeting short peptides and application thereof in inflammatory diseases. 2020-11-24.