Thimerosal (Synonyms: Merthiolate, NSC 4794) |
رقم الكتالوجGC48571
One-Click Copy Product Info
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A mercurial antimicrobial agent
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54-64-8
Sample solution is provided at 25 µL, 10mM.
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Thimerosal is a mercurial antimicrobial agent.1,2 It is bacteriostatic against hemolytic streptococci and fungistatic against H. capsulatum, B. dermatitidis, and S. schenckii. Thimerosal (1-250 µM) induces apoptosis in HCN-1A human cortical neurons and various neuroblastoma cells.3,4 In vivo, thimerosal (80 mg/kg, i.p.) induces footpad swelling and dorsal skin contact dermatitis in a mouse model of pseudo-allergic reaction.5 Formulations containing thimerosal have been used as antiseptics and preservatives in vaccines.
1.Morton, H.E., North, L.L., Jr., and Engley, F.B., Jr.The bacteriostatic and bactericidal actions of some mercurial compounds on hemolytic streptococciJ. Am. Med. Assoc.136(1)37-41(1948) 2.Deighton, F.J., Hall, N.K., and Larsh, H.W.Merthiolate treatment of pathogenic fungiJ. Clin. Microbiol.10(2)144-146(1979) 3.Baskin, D.S., Ngo, H., and Didenko, V.V.Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblastsToxicol. Sci.74361-368(2003) 4.DÓrea, J.G.Integrating experimental (in vitro and in vivo) neurotoxicity studies of low-dose thimerosal relevant to vaccinesNeurochem. Res.36(3)927-038(2011) 5.Peng, B., Che, D., Hao, Y., et al.Thimerosal induces skin pseudo-allergic reaction via Mas-related G-protein coupled receptor B2J. Dermatol. Sci.95(3)99-106(2019)
| Cas No. | 54-64-8 | SDF | |
| المرادفات | Merthiolate, NSC 4794 | ||
| Canonical SMILES | O=C([O-])C1=CC=CC=C1[S][Hg]CC.[Na+] | ||
| Formula | C9H9HgO2S•Na | M.Wt | 404.8 |
| الذوبان | H2O : 100 mg/mL (229.95 mM; Need ultrasonic and warming) | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4704 mL | 12.3518 mL | 24.7036 mL |
| 5 mM | 494.1 μL | 2.4704 mL | 4.9407 mL |
| 10 mM | 247 μL | 1.2352 mL | 2.4704 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 20 reference(s) in Google Scholar.)