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Transferase

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Transferases are a collection of a large and diverse group of enzymes that specifically catalyze the transfer of one or more functional groups from one molecule (the donor) to another (the acceptor). A few transferases involved in this category include farnesyltransferase (FTase), diacylglycerol acyltransferase (DGAT) and catechol-O-methyltransferase (COMT). Ftase catalyzes the transfer of a farnesyl moiety to the cysteine terminal residue (the sulfhydryl cysteine of the CAAS motif)) of substrate proteins. DGAT catalyzes the final step of the triacylglycerol (TG) biosynthetic pathway, where diacylglycerol is esterified to produce TG. COMT catalyzes the methylation of catechol substrates utilizing S-adenosyl-L-methionine (SAM) as a methyl donor and generating O-methylated catechol and S-adenosyl-L-homocysteine.

Products Related to Transferase(21)

  • GC10106 structure
    GC10106OR-486
    CAS: 7659-29-2
    Purity: >98%

    OR-486 (OR-486) هو مثبط قوي لإنزيم الكاتيكول- O- ميثيل ترانسفيراز ، مع IC50 يبلغ 12 نانومتر.

  • GC10265 structure
    GC10265Manumycin A
    CAS: 52665-74-4
    Purity: >98.00%

    مانوميسين أ مضاد حيوي

  • GC10330 structure
    GC10330Lonafarnib
    CAS: 193275-84-2
    Purity: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC10905 structure
    GC10905Amodiaquine dihydrochloride dihydrate
    CAS: 6398-98-7
    Purity: >99.50%

    ثنائي هيدروكلوريد الأمودياكين (Amodiaquin dihydrochloride dihydrate) ، فئة 4-aminoquinoline من العامل المضاد للملاريا ، هو مثبط الهيستامين N- ميثيل ترانسفيراز قوي وفعال عن طريق الفم

  • GC11524 structure
    GC11524Cystamine dihydrochloride
    CAS: 56-17-7
    Purity: >98%

    transglutaminase inhibitor

  • GC11884 structure
    GC11884GPP 78 hydrochloride
    Purity: >98%

    NAMPT inhibitor

  • GC12449 structure
    GC12449SKF 91488 dihydrochloride
    CAS: 68941-21-9
    Purity: >98%

    histamine N-methyltransferase inhibitor

  • GC12912 structure
    GC12912BCATc Inhibitor 2
    CAS: 406191-34-2
    Purity: >99.00%

    مثبط BCATc Inhibitor 2 هو مثبط انتقائي لسلسلة متفرعة من aminotransferase (BCAT) للبحث في الأمراض التنكسية العصبية

  • GC12981 structure
    GC12981OU749
    CAS: 519170-13-9
    Purity: >98%

    γ-Glutamyl transferase (GGT) inhibitor

  • GC14308 structure
    GC14308FK866 (APO866)
    CAS: 658084-64-1
    Purity: >99.50%

    FK866 (APO866) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) (K i =0.3nM).

  • GC15274 structure
    GC15274PF-04620110
    CAS: 1109276-89-2
    Purity: >98.00%

    PF-04620110 is an orally active, selective diacylglycerol acyltransferase-1 (DGAT1) inhibitor (IC 50 = 19nM).

  • GC15442 structure
    GC15442Tipifarnib (Zarnestra)
    CAS: 192185-72-1
    Purity: >98.50%

    A farnesyltransferase inhibitor with antitumor activity

  • GC15614 structure
    GC15614A922500
    CAS: 959122-11-3
    Purity: >98.50%

    A922500 is a potent, selective, and orally bioavailable diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC 50 values of 9 and 22nM against human and mouse DGAT-1, respectively.

  • GC16129 structure
    GC16129LY 78335
    CAS: 39959-66-5
    Purity: >95.00%

    phenylethanolamine-N-methyltransferase (PNMT) inhibitor

  • GC16310 structure
    GC16310FTI 277 HCl
    CAS: 180977-34-8
    Purity: >99.00%

    FTI 277 حمض الهيدروكلوريك هو مثبط ل farnesyl ترانسفيراز (FTase) ؛ محاكٍ ببتيدٍ قوي للغاية Ras CAAX يعاكس إشارات الورم السرطانية H- و K-Ras.

  • GC16612 structure
    GC16612GGsTop
    CAS: 926281-37-0
    Purity: >95.00%

    مثبط γ-غلوتاميل ترانسبيبتيداز (GGT)، جديد ولا يعود.

  • GC16738 structure
    GC16738Tunicamycin Mixture
    CAS: 11089-65-9
    Purity: >95.00%

    مضاد حيوي، يثبط نقل الفوسفات إلى GlcNAc (GPT)

  • GC17046 structure
    GC17046Tris DBA
    CAS: 51364-51-3
    Purity: >98%

    N-myristoyltransferase-1 (NMT-1) inhibitor

  • GC17780 structure
    GC17780FTase Inhibitor II
    CAS: 156707-43-6
    Purity: >98.50%

    Ftase inhibitor

  • GC17921 structure
    GC17921Tolcapone
    CAS: 134308-13-7
    Purity: >98%

    A reversible COMT inhibitor

  • GC10170 structure
    GC10170LB42708
    CAS: 226929-39-1
    Purity: >98%

    LB42708 هو مثبط قوي وانتقائي وناشط عن طريق الفم