Tropisetron-d5 |
رقم الكتالوجGC48208
One-Click Copy Product Info
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A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1220284-86-5
Sample solution is provided at 25 µL, 10mM.
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Tropisetron-d5 is intended for use as an internal standard for the quantification of tropisetron by GC- or LC-MS. Tropisetron is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 5.3 nM).1,2 It is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC50 = 166 nM) and a partial agonist of the α7 nAChR (Ki = 6.9 nM).3,4
1.Mawe, G.M., Branchek, T.A., and Gershon, M.D.Peripheral neural serotonin receptors: Identification and characterization with specific antagonists and agonistsProc. Natl. Acad. Sci. USA83(24)9799-9803(1986) 2.Round, A., and Wallis, D.I.The depolarizing action of 5-hydroxytryptamine on rabbit vagal afferent and sympathetic neurones in vitro and its selective blockade by ICS 205-930Br. J. Pharmacol.88(2)485-494(1986) 3.Shiina, A., Shirayama, Y., Niitsu, T., et al.A randomised, double-blind, placebo-controlled trial of tropisetron in patients with schizophreniaAnn. Gen. Psychiatry9(27)(2010) 4.Rothlin, C.V., Katz, E., Verbitsky, M., et al.The α9 nicotinic acetylcholine receptor shares pharmacological properties with type A γ-aminobutyric acid, glycine, and type 3 serotonin receptorsMol. Pharmacol.55(2)248-254(1999)
| Cas No. | 1220284-86-5 | SDF | |
| Canonical SMILES | CN1[C@@H]2C[C@@H](OC(C3=C([2H])NC4=C3C([2H])=C([2H])C([2H])=C4[2H])=O)C[C@H]1CC2 | ||
| Formula | C17H15D5N2O2 | M.Wt | 289.4 |
| الذوبان | DMSO: slightly soluble,Methanol: slightly soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4554 mL | 17.2771 mL | 34.5543 mL |
| 5 mM | 691.1 μL | 3.4554 mL | 6.9109 mL |
| 10 mM | 345.5 μL | 1.7277 mL | 3.4554 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)