TRPC3 agonist-1 (compound 4n) is a selective and competitive TRPC3 channel agonist. TRPC3 agonist-1 binds at L2 site of hTRPC3 [1].
References:
[1]. Chen Y, et al. Structural mechanism of the agonist binding on human TRPC3 channel. Nat Commun. 2025 Oct 22;16(1):9343.
References:
[1]. Chen Y, et al. Structural mechanism of the agonist binding on human TRPC3 channel. Nat Commun. 2025 Oct 22;16(1):9343.