الصفحة الرئيسية>>Signaling Pathways>> Neuroscience>> mAChR>>(-)-Vesamicol

(-)-Vesamicol

رقم الكتالوجGC70383

(-)-Vesamicol AH5183 هو مثبط لنقل الأسيتيل كولين في الحويصلات المتشابكة، مع IC50 من 75 نانومتر.

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(-)-Vesamicol التركيب الكيميائي

Cas No.: 112709-59-8

الحجم السعر المخزون الكميّة
5 mg
108٫00
متوفر
10 mg
163٫00
متوفر
25 mg
326٫00
متوفر
50 mg
504٫00
متوفر
100 mg
783٫00
متوفر

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مراجعات العميل

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Sample solution is provided at 25 µL, 10mM.

Description of (-)-Vesamicol

(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC50 of 75 nM. (-)-Vesamicol can be used for release and recycling of synaptic vesicles study.

References:
[1]. Searl T, et al. Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium. J Physiol. 1991;444:99-116.

Chemical Properties of (-)-Vesamicol

Cas No. 112709-59-8 SDF
Formula C17H25NO M.Wt 259.39
الذوبان DMSO : 100 mg/mL (385.52 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (-)-Vesamicol

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.8552 mL 19.276 mL 38.552 mL
5 mM 0.771 mL 3.8552 mL 7.7104 mL
10 mM 0.3855 mL 1.9276 mL 3.8552 mL
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In vivo Formulation Calculator (Clear solution) of (-)-Vesamicol

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for (-)-Vesamicol

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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