VU0519975 is a raft destabilizing compound. VU0519975 reduces PMP22 raft partitioning and destabilizes ordered domains. VU0519975 significantly decreases the fraction of phase separated GPMVs [1].
References:
[1]. Stefanski KM, et al. Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function. bioRxiv [Preprint]. 2025 Oct 4:2025.10.03.680351.
References:
[1]. Stefanski KM, et al. Pharmacological Tools to Modulate Ordered Membrane Domains and Order-Dependent Protein Function. bioRxiv [Preprint]. 2025 Oct 4:2025.10.03.680351.
















