XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase ( HADH ) activator. XZA-1 increases the intracellular level of acetoacetyl-CoA, which in turn induces acetoacetylation modification of Chromobox Protein Homolog 4 ( CBX4 ) at lysine 106 (K106). XZA-1 exhibits antitumor effects in a xenograft model of human hepatocellular carcinoma SMMC7721 cells overexpressing CBX4. XZA-1 can be used for the study of hepatocellular carcinoma [1].
References:
[1]. Li H, et al. CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity. Cell Chem Biol. 2025 Oct 16;32(10):1249-1259.e9.
References:
[1]. Li H, et al. CBX4 acetoacetylation as an inhibitory mechanism of HIF-1α activity. Cell Chem Biol. 2025 Oct 16;32(10):1249-1259.e9.