Arenavirus

An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans.

Arenaviruses are a diverse family of small, enveloped, single-stranded RNA viruses which are generally propagated through asymptomatic, chronic infection of specific rodent hosts. Several arenaviruses are significant human pathogens, including five distinct hemorrhagic fever viruses designated category A by the CDC and NIAID, which is indicative of the level of highest threat to civilian populations. Several arenaviruses, including Lassa virus (LASV), are causative agents of hemorrhagic fever, for which effective therapeutic options are lacking.

The convergence of sensitivity to diverse small-molecule inhibitors thus identifies a robust new target for arenavirus antiviral discovery within the viral entry phase.

Products Related to Arenavirus(10)

GC28055 VV261
CAS: 3003864-86-3
Purity: >99.50%
VV261 is an orally active prodrug of 4'-fluorouridine. VV261 inhibits viral RNA-dependent RNA polymerase.
GC18485 Retro-2
CAS: 1429192-00-6
Purity: >98.00%
Retro-2 is a potent ebolavirus (EBOV) infection inhibitor with an EC 50 value of 12.2μM.
GC34252 GP(33-41)
CAS: 161928-86-5
Purity: >98%
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM.
GC34375 ST-193 hydrochloride
CAS: 2320274-72-2
Purity: >98.50%
ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
GC37681 ST-193
CAS: 489416-12-8
Purity: >99.50%
ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
GC37751 Tecovirimat
CAS: 869572-92-9
Purity: >98%
GC65001 LHF-535
CAS: 1450929-77-7
Purity: >99.00%
LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
GC65488 GP(33-41) TFA
Purity: >99.50%
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus.
GC69363 LCMV GP (61-80)
CAS: 232598-19-5
Purity: >98.00%
LCMV GP (61-80) is a peptide fragment derived from the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), corresponding to amino acid sequence 61-80. LCMV GP (61-80) is a specific antigenic determinant that can induce CD4+ T cell responses.
GN10629 5,7-dihydroxychromone
CAS: 31721-94-5
Purity: >99.00%
5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC28055	VV261	3003864-86-3	>99.50%
GC28055	VV261 is an orally active prodrug of 4'-fluorouridine. VV261 inhibits viral RNA-dependent RNA polymerase.
GC18485	Retro-2	1429192-00-6	>98.00%
GC18485	Retro-2 is a potent ebolavirus (EBOV) infection inhibitor with an EC 50 value of 12.2μM.
GC34252	GP(33-41)	161928-86-5	>98%
GC34252	GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM.
GC34375	ST-193 hydrochloride	2320274-72-2	>98.50%
GC34375	ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
GC37681	ST-193	489416-12-8	>99.50%
GC37681	ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
GC37751	Tecovirimat	869572-92-9	>98%
GC65001	LHF-535	1450929-77-7	>99.00%
GC65001	LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
GC65488	GP(33-41) TFA	-	>99.50%
GC65488	GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus.
GC69363	LCMV GP (61-80)	232598-19-5	>98.00%
GC69363	LCMV GP (61-80) is a peptide fragment derived from the glycoprotein (GP) of lymphocytic choriomeningitis virus (LCMV), corresponding to amino acid sequence 61-80. LCMV GP (61-80) is a specific antigenic determinant that can induce CD4+ T cell responses.
GN10629	5,7-dihydroxychromone	31721-94-5	>99.00%
GN10629	5,7-dihydroxychromone, a flavonoid decomposition product from peanut shells, inhibits the radicle elongation of velvetleaf, corn, peanut, and wheat.