Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity. After displacement of the 2 long-chain aliphatic leaving groups (neodecanoic acid), platinum diaminocyclohexane (DACH) complexes become highly reactive and alkylate macromolecules, forming both inter- and intra-strand DNA crosslinks and inhibiting DNA synthesis, which results in tumor cell cytotoxicity. Because DNA mismatch-repair (MMR) complexes do not recognize DACHÂ-platinum adducts, DNA repair mechanisms are inhibited, overcoming limitations observed with other platinum-based agents. In addition, the liposomal encapsulation improves the bioavailability of NDDP and reduces its toxicity profile.
Aroplatin
Catalog No.: GB62172Purity:>98%Synonyms: Aroplatin; L-NDDP; NDDP;
Aroplatin is a synthetic liposomal formulation of bis-neodecanoate diaminocyclohexane platinum (NDDP), a third-generation platinum complex analogue of cisplatin, with potential antineoplastic activity.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114488-24-3
1mgIn Stock
$90.00
1
5mgIn Stock
$150.00
1
10mgIn Stock
$250.00
1
25mgIn Stock
$550.00
1
50mgIn Stock
$950.00
1
100mgIn Stock
$1,650.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $90.00 | In Stock | 1 | |
| 5mg | $150.00 | In Stock | 1 | |
| 10mg | $250.00 | In Stock | 1 | |
| 25mg | $550.00 | In Stock | 1 | |
| 50mg | $950.00 | In Stock | 1 | |
| 100mg | $1,650.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Chemical Properties
CAS No.
114488-24-3
Synonyms
Aroplatin; L-NDDP; NDDP;
SMILES
CC(C)(CCCCCC(O[Pt-2]1([NH2+]C2C(CCCC2)[NH2+]1)OC(CCCCCC(C)(C)C)=O)=O)C
Molecular Formula
C26H52N2O4Pt
Molecular Weight
651.796
Solubility
Soluble in DMSO, not in water
Storage
Store at-20℃
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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