Azeliragon, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor. RAGE (receptor for advanced glycation endproducts) is a pattern recognition receptor, which affects the movement of amyloid, an Alzheimer's-associated protein, into the brain. In preclinical studies, azeliragon decreased brain amyloid in mice and improved their performance on behavior tests. Azeliragon is a promising agent for for Alzheimer's disease and cerebral amyloid angiopathy.
Azeliragon HCl
Catalog No.: GB62197Purity:>98%Synonyms: Azeliragon HCl; Azeliragon hydrochloride; Azeliragon dihydrochloride; TTP488 HCl; TTP-488; TTP 488; PF-04494700; PF 04494700; PF04494700.
Azeliragon, also known as TTP488 and PF-04494700, is a potent and orally active RAGE inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1284150-65-7
10mgIn Stock
$150.00
1
25mgIn Stock
$250.00
1
50mgIn Stock
$450.00
1
100mgIn Stock
$750.00
1
200mgIn Stock
$1,250.00
1
500mgIn Stock
$2,650.00
1
1gIn Stock
$3,650.00
1
2gIn Stock
$6,250.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mg | $150.00 | In Stock | 1 | |
| 25mg | $250.00 | In Stock | 1 | |
| 50mg | $450.00 | In Stock | 1 | |
| 100mg | $750.00 | In Stock | 1 | |
| 200mg | $1,250.00 | In Stock | 1 | |
| 500mg | $2,650.00 | In Stock | 1 | |
| 1g | $3,650.00 | In Stock | 1 | |
| 2g | $6,250.00 | In Stock | 1 |
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Citations
No citations are currently available for this product. Below are selected publications citing GlpBio products.
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
Description
Chemical Properties
CAS No.
1284150-65-7
Synonyms
Azeliragon HCl; Azeliragon hydrochloride; Azeliragon dihydrochloride; TTP488 HCl; TTP-488; TTP 488; PF-04494700; PF 04494700; PF04494700.
SMILES
CCN(CC)CCCOC1=CC=C(C2=CN(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)C(CCCC)=N2)C=C1.[H]Cl.[H]Cl
Molecular Formula
C32H40Cl3N3O2
Molecular Weight
605.041
Solubility
Soluble in DMSO
Storage
Store at-20℃
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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