GLPBio

BAY 59-9435

Catalog No.: GC74756Purity:>98.00%
COASDSData Sheet
BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.

Products are for research use only. Not for human use. We do not sell to patients.

BAY 59-9435
Cas No.: 654059-21-9
1 mgIn Stock
$123.00
1
5 mgIn Stock
$270.00
1
10 mgIn Stock
$441.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.

BAY 59-9435 significantly diminishes the isoproterenol-increased media IL-6. BAY 59-9435 blocks isoproterenol-induced SphK1 expression[3].

References:
[1]. Ebdrup S, et al. Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase. J Med Chem. 2004 Jan 15;47(2):400-10.
[2]. Elizabeth A Rondini, et al. Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown AdipocytesJ Pharmacol Exp Ther. 2017 Dec;363(3):367-376.
[3]. Wenliang Zhang, et al. Adipocyte lipolysis-stimulated interleukin-6 production requires sphingosine kinase 1 activity. J Biol Chem. 2014 Nov 14;289(46):32178-85.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
654059-21-9
Molecular Formula
C14H22N2O3
Molecular Weight
266.34
Solubility
DMSO: 100 mg/mL (375.46 mM; Need ultrasonic)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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