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BMS-223131 (Synonyms: BMS-223131; BMS 223131; BMS223131)

Catalog No.GB62296 Copy One-Click Copy Product Info

BMS-223131 is a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels.

Products are for research use only. Not for human use. We do not sell to patients.

BMS-223131 Chemical Structure

Cas No.: 275375-69-4

Size Price Stock Qty
1mg
$150.00
In stock
5mg
$450.00
In stock
10mg
$750.00
In stock
25mg
$1,250.00
In stock
50mg
$2,050.00
In stock
100mg
$3,450.00
In stock

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Customer Reviews

Based on customer reviews.

Sample solution is provided at 25 µL, 10mM.



Description of BMS-223131

BMS-223131 is a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels. BMS-223131 effectively reduced stress-induced colonic motility and visceral nociception supporting the potential utility of maxi-K channel openers for the treatment of bowel disorders involving dysfunctional motility and visceral sensitivity.

Chemical Properties of BMS-223131

Cas No. 275375-69-4 SDF
Synonyms BMS-223131; BMS 223131; BMS223131
Canonical SMILES C1=CC2=C(C=C1C(F)(F)F)C(=C(C(=O)N2)CCO)C3=C(C=CC(=C3)Cl)O
Formula C18H13ClF3NO3 M.Wt 383.7512
Solubility To be determined Storage Store at-20℃
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of BMS-223131

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1 mg 5 mg 10 mg
1 mM 2.6059 mL 13.0293 mL 26.0586 mL
5 mM 521.2 μL 2.6059 mL 5.2117 mL
10 mM 260.6 μL 1.3029 mL 2.6059 mL
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In vivo Formulation Calculator (Clear solution) of BMS-223131

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Reviews

Review for BMS-223131

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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