BPH-1358 (Synonyms: NSC 50460) |
| Catalog No.GC52240 |
An inhibitor of UPPS and FPPS
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5352-53-4
Sample solution is provided at 25 µL, 10mM.
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BPH-1358 is an inhibitor of undecaprenyl diphosphate synthase (UPPS; IC50 = 0.11 µM for the E. coli and S. aureus enzymes), an enzyme involved in bacterial cell wall biosynthesis.1 It is also an inhibitor of farnesyl diphosphate synthase (FPPS; IC50 = 1.8 µM for the human enzyme), an enzyme in the mevalonate pathway of cholesterol and isoprenoid biosynthesis.2 BPH-1358 is active against E. coli and S. aureus (EC50s = 0.3 and 0.29 nM, respectively) and increases survival in a mouse model of S. aureus infection when administered at a dose of 10 mg/kg.1
1.Zhu, W., Wang, Y., Li, K., et al.Antibacterial drug leads: DNA and enzyme multitargetingJ. Med. Chem.58(3)1215-1227(2015) 2.Lindert, S., Zhu, W., Liu, Y.-L., et al.Farnesyl diphosphate synthase inhibitors from in silico screeningChem. Biol. Drug Des.81(6)742-748(2013)
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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