GLPBio

C1s-IN-1 trihydrochloride

Catalog No.: GC82514Purity:>99.50%
COASDSData Sheet
C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the K i of 5.8 μM.

Products are for research use only. Not for human use. We do not sell to patients.

C1s-IN-1 trihydrochloride
Cas No.: 1376162-36-5
10mM (in 1mL DMSO)In Stock
$55.00
1
25mgIn Stock
$50.00
1
50mgIn Stock
$83.00
1
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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Description

C1s-IN-1 trihydrochloride (Compound A1) is the selective inhibitor for C1s protease with the K i of 5.8 μM. C1s-IN-1 trihydrochloride inhibits cleavage of C2 by C1s with an IC50 of 85 μM, inhibits the activation of classic pathway with an IC50 of 22 μM. C1s-IN-1 trihydrochloride is the competitive inhibitor for thrombin with the K i of 51.2 μM [1].

References:
[1]. Xu X, et al., Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212(4):689-701.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1376162-36-5
Molecular Formula
C16H22Cl3N5
Molecular Weight
390.74
Solubility
DMSO: 100 mg/mL (255.92 mM; Need ultrasonic)
Storage
Store at 4°C, sealed storage, away from moisture
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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