CAY10700 |
| Catalog No.GC18710 |
Prostaglandin E2 is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1381846-21-4
Sample solution is provided at 25 µL, 10mM.
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Prostaglandin E2 is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both COX-2 and microsomal PGE synthase-1 (mPGES-1). CAY10700 is an orally bioavailable inhibitor of mPGES-1 (IC50 = 0.24 uM in an in vitro human whole blood assay). It is inactive against COX-1 and COX-2 (9% inhibition at 100 uM and 16% at 30 uM, respectively).
References:
[1].Schiffler, M.A., Antonysamy, S., Bhattachar, S.N., et al. Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors Journal of Medicinal Chemistry 59(1), 194-205 (2016).
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GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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