GLPBio

CD73

Read More about this category

CD73 (Ecto-5′-nucleotidase), a component of the purinergic signaling pathway, is a 70-kD glycosylphosphatidylinositol-anchored cell surface protein encoded by the NT5E gene.

CD73 has both enzymatic and non-enzymatic functions in cells. As a nucleotidase, CD73 catalyzes the hydrolysis of AMP into adenosine and phosphate, and CD73-generated adenosine plays an important role in tumor immunoescape. CD73 plays a crucial role in switching on adenosinergic signaling. CD73 also functions as a signal and adhesive molecule that can regulate cell interaction with extracellular matrix components, such as laminin and fibronectin, to mediate the invasive and metastatic properties of cancers. Both the enzymatic and non-enzymatic functions of CD73 are involved in cancer-associated processes and are not completely independent of each other.

Overexpression of CD73 is associated with resistance to antitumor agents. Knockdown of CD73 inhibits in vitro cell growth, cell cycle progression and cell migration in many cancers. CD73 and its associated pathways may be useful as therapeutic targets.

Products Related to CD73(15)

  • GC31914 structure
    GC31914CD73-IN-1
    CAS: 2132396-40-6
    Purity: >98.50%

    CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80.

  • GC32795 structure
    GC32795PSB-12379
    CAS: 1802226-78-3
    Purity: >99.50%

    An inhibitor of CD73

  • GC36587 structure
    GC36587MethADP
    CAS: 3768-14-7
    Purity: >99.50%

    MethADP is a specific CD73 inhibitor.

  • GC36588 structure
    GC36588MethADP sodium salt
    CAS: 89016-30-8
    Purity: >98%

    MethADP (sodium salt) is a specific CD73 inhibitor.

  • GC62331 structure
    GC62331CD73-IN-3
    CAS: 2375815-63-5
    Purity: >99.50%

    CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research.

  • GC62452 structure
    GC62452CD73-IN-4
    CAS: 2216764-29-1
    Purity: >99.50%

    CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73.

  • GC62694 structure
    GC62694OP-5244
    CAS: 2381268-71-7
    Purity: >99.50%

    OP-5244 is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM.

  • GC62695 structure
    GC62695OP-5244 sodium
    Purity: >98%

    OP-5244 sodium is a potent and orally active inhibitor of CD73, with an IC50 of 0.25 nM.

  • GC65293 structure
    GC65293AB-680
    CAS: 2105904-82-1
    Purity: >98.00%

    AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

  • GC65470 structure
    GC65470Oleclumab
    CAS: 1803176-05-7
    Purity: >98.00%

    Oleclumab (MEDI9447) is a human IgG1λ anti-CD73 monoclonal antibody that inhibits CD73 function. Oleclumab has an anti-tumor activity.

  • GC68344 structure
    GC68344Mupadolimab
    CAS: 2451856-97-4
    Purity: >98%
  • GC68346 structure
    GC68346Uliledlimab
    CAS: 2378407-27-1
    Purity: >98%
  • GC68386 structure
    GC68386CD73-IN-5
    CAS: 2412019-99-7
    Purity: >98%
  • GC69453 structure
    GC69453MethADP triammonium
    Purity: >99.00%

    MethADP (Adenosine 5'-(α,β-methylene)diphosphate) triammonium is a CD73 inhibitor. MethADP can be used for research on the ATP-adenosine pathway.

  • GC79353 structure
    GC793532,4-Dinitrobenzenesulfonic acid
    CAS: 89-02-1
    Purity: >98.00%

    2,4-Dinitrobenzenesulfonic acid (Compound 3) is a ecto-5'-Nucleotidase ( CD73 ) inhibitor with a K i value of 63 μM for human and 144 μM for rat.