Conimine TFA |
Catalog No.GC78835
One-Click Copy Product Info
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Conimine TFA is a steroidal alkaloid, antibacterial agent and potentiator.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vitro, Conimine (two-fold serial dilutions; 24 h) TFA inhibits the growth of methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA) with an MIC of 128 μg·mL−1 for both strains[1]. Conimine (1/64-1 of its MIC (128 μg·mL-1)) TFA exhibits synergistic antibacterial activity with penicillin against methicillin-resistant Staphylococcus aureus (MRSA) and with vancomycin against both methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA), while showing a nonrelative effect with penicillin against MSSA[1].
References:
[1]. Zhou LN, et al. Antibacterial steroidal alkaloids from Holarrhena antidysenteriaca. Chin J Nat Med. 2017;15(7):540-545.
| Cas No. | SDF | ||
| Formula | C24H37F3N2O2 | M.Wt | 442.56 |
| Solubility | DMSO: 50 mg/mL (112.98 mM; Need ultrasonic) | Storage | Store at 4°C, stored under argon |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2596 mL | 11.2979 mL | 22.5958 mL |
| 5 mM | 451.9 μL | 2.2596 mL | 4.5192 mL |
| 10 mM | 226 μL | 1.1298 mL | 2.2596 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)