CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier[1].
CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively[1].
[1]. Grijota-MartÍnez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42.