DL-Glyceric Acid (20% in water) is a highly polar chiral carboxylic acid in urine[1]. DL-Glyceric Acid can be used as a carbon source to screen microorganisms that selectively degrade D-Glyceric Acid from DL-Glyceric Acid, thereby producing L-Glyceric Acid with high enantiomeric purity[2]. DL-glyceric acid has been widely used as an internal standard to optimize the parameters of high-performance liquid chromatography for the efficient identification of related compounds[3].
References:[1] Rashed M S, Aboul‐Enein H Y, AlAmoudi M, et al. Chiral liquid chromatography tandem mass spectrometry in the determination of the configuration of glyceric acid in urine of patients with d‐glyceric and l‐glyceric acidurias[J]. Biomedical Chromatography, 2002, 16(3): 191-198.
[2] Sato S, Morita T, Fukuoka T, et al. Microbial resolution of dl-glyceric acid for l-glyceric acid production with newly isolated bacterial strains[J]. Journal of bioscience and bioengineering, 2015, 119(5): 554-557.
[3] Zhang W, Ye L, Xu S, et al. Stereoretentive transformation of biomass hexoses into optically pure glyceric acid at near‐ambient temperature[J]. AIChE Journal, 2026: e70492.