Fmoc-Hyp(tBu)-OH is a derivative of hydroxyproline and is commonly used as a building block in peptide synthesis [1]. Fmoc-Hyp(tBu)-OH can be used in the solid-phase peptide synthesis (SPPS) process to prepare glycopeptides with long peptide chains[2]. Fmoc-Hyp(tBu)-OH can be used in the stepwise chain elongation method to synthesize heterotrimeric collagen peptides containing functional epitopes[3].
References:
[1] Shoulders M D, Kotch F W, Choudhary A, et al. The aberrance of the 4 S diastereomer of 4-hydroxyproline[J]. Journal of the American Chemical Society, 2010, 132(31): 10857-10865.
[2] van de Sande J W, Albada B. Chemical synthesis of glycopeptides containing L-arabinosylated hydroxyproline and sulfated tyrosine[J]. Organic Letters, 2023, 25(11): 1907-1911.
[3] Ottl J, Jürgen Musiol H, Moroder L. Heterotrimeric collagen peptides containing functional epitopes. Synthesis of single‐stranded collagen type I peptides related to the collagenase cleavage site[J]. Journal of Peptide Science: An Official Publication of the European Peptide Society, 1999, 5(2): 103-110.