GLPBio

18α-Glycyrrhetinic acid

Catalog No.: GC35061Purity:>98.00%Synonyms: Arthrodont, Biosone, Enoxolone, α-Glycyrrhetinic Acid, GM 1658, NSC 35347, PO 12, STX 352
COASDSData Sheet
18α-Glycyrrhetinsäure, eine aus der Nahrung gewonnene Verbindung, ist ein Inhibitor von NF-kB und ein Aktivator des Proteasoms, das als Pro-Langlebigkeits- und Anti-Aggregationsfaktor in einem vielzelligen Organismus dient.

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18α-Glycyrrhetinic acid
Cas No.: 1449-05-4
10mM (in 1mL DMSO)In Stock
$15.00
1
10mgIn Stock
$13.00
1
25mgIn Stock
$27.00
1
50mgIn Stock
$43.00
1
100mgIn Stock
$69.00
1
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Beschreibung (Description)

18α-Glycyrrhetinic acid is a bioactive triterpenoid mainly derived from Glycyrrhiza radix. 18α-Glycyrrhetinic acid has various pharmacological activities such as anti-oxidative and anti-inflammatory[1]. 18α-Glycyrrhetinic acid can inhibit oxidative stress via activating Nrf-2 signaling[1].

18α-Glycyrrhetinic acid (8μM; 72h) inhibited cell growth in Human HSC cells[2]. 18α-Glycyrrhetinic acid (4μg/mL; 24h) significantly reduced ROS (reactive oxygen species) production in fructose-treated HK2 cells[3]. 18α-Glycyrrhetinic acid (50μM; 48h) decreased the cell viability in Caco-2 cells[4]. 18α-Glycyrrhetinic acid (2μg/mL; 24h) increased the cell viability in mitomycin C-induced HFL-1 cells[1].

18α-Glycyrrhetinic acid (10mg/kg; 30d; q2d; i.p.) significantly decreased the expression of CD40 and MHC-II molecules in BALB/c mice[5]. 18α-Glycyrrhetinic acid (12.5, 25 and 50mg/kg; 12 weeks; p.o.) alleviated fructose-induced renal injury in C57BL/6 mice[3].

References:
[1] Lefaki M, Papaevgeniou N, Tur J A, et al. The dietary triterpenoid 18α-glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway [J]. Redox biology, 2020, 28: 101317.
[2] Zong L, Qu Y, Xu M Y, et al. 18α-Glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line [J]. Journal of digestive diseases, 2013, 14(6): 328-336.
[3] Cheng X, Qiu L, Wang F. 18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in mice by suppressing oxidative stress, dyslipidemia and inflammation [J]. Biomedicine & pharmacotherapy, 2020, 125: 109702.
[4] Malekinejad M, Pashaee M R, Malekinejad H. 18β-Glycyrrhetinic acid altered the intestinal permeability in the human Caco-2 monolayer cell model [J]. European journal of nutrition, 2022, 61(7): 3437-3447.
[5] Ebrahimnezhad S, Amirghofran Z, Karimi M H. Decline in immunological responses mediated by dendritic cells in mice treated with 18α-glycyrrhetinic acid [J]. Immunological investigations, 2016, 45(3): 191-204.

Protokoll (Protocol)

Cell experiment [1]:

Cell lines

Human HSC cell line

Preparation Method

 2×104 cells per well were seeded onto 24-well plates and incubated overnight. After starvation for 24h, the cells were subsequently stimulated with 10% FBS with or without the presence of 18α-Glycyrrhetinic acid. The number of cells was determined by computer-equipped cell counter 72h after treated with 18α-Glycyrrhetinic acid.

Reaction Conditions

8μM; 72h

Applications

 18α-Glycyrrhetinic acid inhibited cell growth.
Animal experiment [2]:

Animal models

 BALB/c mice

Preparation Method

18α-Glycyrrhetinic acid solution was prepared in DMSO. A concentration of 10mg 18α-Glycyrrhetinic acid per kilogram of each mouse was used to be intraperitoneally injected in test group every other day within 30 consecutive days. The mice in the control group were treated with 2% DMSO (equal to the test group) as a vehicle in PBS. The expression of co-stimulatory molecules CD40 and MHC-II on isolated dendritic cells from mice were investigated by flow cytometry.

Dosage form

10mg/kg; 30d; q2d; i.p.

Applications

18α-Glycyrrhetinic acid significantly decreased the expression of CD40 and MHC-II molecules.
References:
[1] Zong L, Qu Y, Xu M Y, et al. 18α-Glycyrrhetinic acid extracted from Glycyrrhiza radix inhibits proliferation and promotes apoptosis of the hepatic stellate cell line [J]. Journal of digestive diseases, 2013, 14(6): 328-336.
[2] Ebrahimnezhad S, Amirghofran Z, Karimi M H. Decline in immunological responses mediated by dendritic cells in mice treated with 18α-glycyrrhetinic acid [J]. Immunological investigations, 2016, 45(3): 191-204.

Produktdokumente (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemische Eigenschaften (Chemical Properties)

CAS-Nr.
1449-05-4
Synonyme
Arthrodont, Biosone, Enoxolone, α-Glycyrrhetinic Acid, GM 1658, NSC 35347, PO 12, STX 352
SMILES
CC1(C)[C@@H](O)CC[C@@]2(C)[C@@]1([H])CC[C@]([C@@](CC[C@]3(C)[C@]4([H])C[C@@](C)(C(O)=O)CC3)(C)C4=C5)(C)[C@]2([H])C5=O
Summenformel
C30H46O4
Molekulargewicht
470.68
Löslichkeit
DMF: 13 mg/ml,DMSO: 16 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH7.2) (1:7): 0.13 mg/ml
Lagerung
Store at -20°C
Versandbedingungen
Evaluierungsmuster werden mit Kühlakkus versandt. Andere verfügbare Größen werden bei Raumtemperatur oder auf Anfrage mit Kühlakkus versandt.

Rechner (Calculators)Molarität / Verdünnung / Molekulargewicht / Einheitenumrechnung / In-vivo-Formulierung / Löslichkeit

g/mol

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