2,2'-Dithiobis(pyridine-N-oxide)

Dipyrithione (20鈥壩糶/mL) shows antifungal activity with MIC values of 6.03 碌M for Trichophyton rubrum^[1].
Dipyrithione (72 h) shows cytotoxic activity against 293鈥塗 cells with an IC₅₀ value of 0.22 碌M^[1].
Dipyrithione (1-5 碌M; 8.5 h) inhibits LPS (100 ng/ml)-induced up-regulation of iNOS and COX-2 in RAW264.7 cells in a dose-dependent manner^[2].
Dipyrithione (1 碌M; 8.5 h) suppresses LPS-induced increase of iNOS but not COX-2 mRNA level, inhibits LPS-increased NO production^[2].
Dipyrithione (3 碌M; 2, 5 h) decreases phosphorylation of STAT1 induced by LPS and does not influence LPS-induced MAPK and NF-魏B activation in RAW 246.7 cells^[2].
Dipyrithione (0-5 渭g/mL; 48 h) shows antiproliferative activity for KB, 231, U937 and K562 cells in a dose dependent manner^[3].
Dipyrithione (2.5 渭g/ml) induces apoptosis and cycle arrest at G1 phase^[3].

Dipyrithione (0.2 mg/cm²; externally once daily for 10 days) shows great anti-dermatophyte activity effects in guinea pig^[1].
Dipyrithione (1, 2.5, 5 mg/kg; i.p.) shows anti-inflammatory activity in mouse^[2].Dipyrithione (5 mg/kg; i.p.; daily for 10 days) shows anti-tumor acyivity in mouse^[3].