Emodin-6-O-尾-D-glucoside (0~20 渭M; 24 hours; HUVECs) does not affect cell viability[1].
Emodin-6-O-尾-D-glucoside (0~10 渭M; 6 hours; HUVECs) results in a dose dependent decrease in high glucose-mediated membrane disruption, inhibits high glucose-induced increase expression of VCAM-1, ICAM-1 and E-selectin and results in decreased expression levels of high glucose-induced MCP-1 and IL-8 mRNA[1].
Emodin-6-O-尾-D-glucoside (10 渭M; 6 hours; HUVECs) results in a decrease in the number of THP-1 cells adhering to high glucose-induced HUVECs[1].
Emodin-6-O-尾-D-glucoside pretreatment significantly inhibits high-glucose-induced ROS formation and p65 NF-魏B expression levels increase[1].
Emodin-6-O-尾-D-glucoside (0~9 mg/mouse; i.v.) markly inhibits peritoneal leakage of dye induced by high glucose[1].
[1]. Lee W, et al. Emodin-6-O-尾-D--glucoside inhibits high-glucose-induced vascular inflammation. Inflammation. 2014;37(2):306-313.