Histone H3K36Me3 (31-41) (trifluoroacetate salt)

Histone H3K36Me3 (31-41) is a peptide fragment of histone H3 that corresponds to amino acid residues 32-42 of the human histone H3.3 sequence. Unlike histone H3.1 and H3.2, the histone H3.3 variant contains a serine residue at position 31 that is phosphorylated during late prometaphase and metaphase of mitosis.¹ Trimetlation of H3K36 is increased in the G₁ and early S phases of the cell cycle where it binds to and recruits the mismatch recognition protein MutSα in preparation for DNA replication and mismatch repair.² H3K36 trimetlation is found in greater amounts on exons compared with introns in C. elegans, mouse, and human genome-wide maps of histone H3 tail metlations.³