Cyclooxygenase

Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.

CTA2 is a stable analog of TXA2.

6-keto Prostaglandin F1α-d4 (6-keto PGF1α-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions.

Prostaglandin A1 (PGA1) ethyl ester is a prodrug form of PGA1 with enhanced lipid solubility.

CAY10526 ist ein spezifischer Inhibitor der mikrosomalen PGE2-Synthase-1 (mPGES1). CAY10526 hemmt die PGE2-Produktion durch die selektive Modulation der mPGES1-Expression, wirkt sich jedoch nicht auf COX-2 aus. CAY10526 unterdr&Uuml;ckt signifikant das Tumorwachstum und erh&Ouml;ht die Apoptose in Melanom-Xenotransplantaten. CAY10526 reduziert die Proteinspiegel von BCL-2 und BCL-XL (anti-apoptotisch) und erh&Ouml;ht die Spiegel von BAX und BAK (pro-apoptotisch) sowie gespaltener Caspase 3. CAY10526 hemmt die Zelllebensf&Auml;higkeit (IC50<5 μM) in drei Melanom-Zelllinien, die mPGES1 exprimieren.

PGF1β is the C-9 epimer of PGF1α.

A stable analog of PGF 2α 2glyceryl ester

Prostaglandin D1(PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl.

AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 µM, respectively).

Prostaglandins have a short life in vivo because NAD+-dependent 15-hydroxy prostaglandin dehydrogenase (15-PGDH) catalyzes their oxidation to 15-keto metabolites with greatly reduced biological activity.

The actions of many clinical prostaglandins, including those used for estrous synchronization and for reduction of intraocular pressure, are mediated through the FP receptor.

Prostaglandin F2α alcohol (PGF2α-OH) is an analog of PGF2α in which the C-1 carboxyl group has been reduced to a primary alcohol.

Prostaglandin F1α (PGF1α) alcohol is an analog of PGF1α with a primary alcohol replacing the C-1 carboxyl group.

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.

Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of DGLA, but to date it has not been isolated as a natural product.

13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase.

5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

Teleocidin A1 (Lyngbyatoxin A), ein hochgiftiger Hautreizstoff, ist ein starker Aktivator der Proteinkinase C (PKC). Teleocidin A1 zeigt antiproliferative Aktivit&Auml;t gegen HeLa-Krebszellen (IC50 = 9,2 nM).

Limaprost-d3 is intended for use as an internal standard for the quantification of limaprost by GC- or LC-MS.

5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.

Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.

11-deoxy PGF2α is a synthetic analog of PGF2α.

11-deoxy Prostaglandin F2β (11-deoxy PGF2β) is an analog of PGF2β.