Amyloid β protein
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Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold.
The normal function of Aβ is not well understood. Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, several potential activities have been discovered for Aβ, including activation of kinase enzymes, protection against oxidative stress, regulation of cholesterol transport, functioning as a transcription factor, and anti-microbial activity (potentially associated with Aβ's pro-inflammatory activity).
The glymphatic system clears metabolic waste from the mammalian brain, and in particular amyloid beta. Indeed, a number of proteases have been implicated by both genetic and biochemical studies as being responsible for the recognition and degradation of amyloid beta; these include insulin degrading enzyme.and presequence protease. The rate of removal is significantly increased during sleep. However, the significance of the lymphatic system in Aβ clearance in Alzheimer's disease is unknown.
Products Related to Amyloid β protein(166)
- GC37984β-Amyloid (1-42), ratCAS: 166090-74-0Purity: >95.00%
β-Amyloid (1-42), Ratte, ist ein Peptid mit 42 AminosÄuren, zeigt eine zytotoxische Wirkung auf akute Hippocampus-Schnitte und wird in der Erforschung der Alzheimer-Krankheit verwendet.
- GC37985β-Amyloid 11-22CAS: 885323-98-8Purity: >98%
β-Amyloid 11-22 ist ein Peptidfragment von β-Amyloid.
- GC37986β-Amyloid 1-17CAS: 186319-72-2Purity: >98%
β-Amyloid 1-17 ist ein Peptid von β-Amyloid, stabilisiert die Fasern und spielt eine Rolle bei der Aβ-Faserbildung.
- GC37987β-Amyloid 1-20CAS: 186319-68-6Purity: >98%
β-Amyloid 1-20 besteht aus den Aminosäuren 1 bis 20 des Beta-Amyloid-Proteins.
- GC37988β-Amyloid 12-20CAS: 134649-29-9Purity: >98%
β-Amyloid 12-20 ist ein Peptidfragment von β-Amyloid.
- GC37989β-Amyloid 13-27CAS: 148270-13-7Purity: >98%
β-Amyloid 13-27 ist ein Peptid, das aus den Aminosäuren 13 bis 27 des Beta-Amyloid-Proteins besteht.
- GC37990β-Amyloid 1-34CAS: 186359-65-9Purity: >98%
β-Amyloid 1-34 ist ein β-Amyloid-Peptid, das aus 34 Aminosäuren besteht.
- GC37992β-Amyloid 18-28CAS: 112163-49-2Purity: >98%
β-Amyloid 18-28 ist ein Peptidfragment von β-Amyloid.
- GC37993β-Amyloid 1-9CAS: 147529-30-4Purity: >98%
β-Amyloid 1-9, ein N-terminales Fragment von Beta-Amyloid, besteht aus den Aminosäureresten 1 bis 9.
- GC37994β-Amyloid 22-40CAS: 1206779-25-0Purity: >98%
β-Amyloid 22-40 ist ein Peptidfragment von β-Amyloid.
- GC37995β-Amyloid 33-40CAS: 634204-57-2Purity: >98%
β-Amyloid 33-40 ist ein Peptid, das aus den Aminosäuren 33 bis 40 des Beta-Amyloid-Proteins besteht.
- GC37996β-Amyloid 35-42CAS: 183292-41-3Purity: >98.00%
β-Amyloid 35-42 ist ein Peptid, das aus den Aminosäuren 35 bis 42 des Beta-Amyloid-Proteins besteht.
- GC37997β-Amyloid 4-10CAS: 477284-32-5Purity: >98%
β-Amyloid 4-10 ist ein Epitop für den polyklonalen Anti-Aβ(1-42)-Antikörper, reduziert die Amyloidablagerung in einem transgenen Mausmodell der Alzheimer-Krankheit.
- GC37998β-Amyloid Protein Precursor 770 135-155CAS: 315229-44-8Purity: >98%
β-Amyloid Protein Precursor 770 135-155 ist ein Peptid der Isoform des Amyloid-Vorläuferproteins (APP 770).
- GC40126Amyloid-β Precursor Protein (96-110) Peptide (cyclized) (human) (trifluoroacetate salt)Purity: >95.00%
Amyloid-β precursor protein (96-110) peptide (cyclized) is a synthetic peptide consisting of amino acids 96-110 of amyloid precursor peptide (APP) that is cyclized via a bridge between the cysteine residues at positions 3 and 10.
- GC40127Amyloid-β (22-35) Peptide (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (Aβ) (22-35) is a 13-residue fragment of Aβ that corresponds to residues 693-705 of the human amyloid precursor protein (APP) full-length sequence.
- GC40128TAMRA-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
TAMRA-Amyloid-β (1-40) peptide is a fluorescently labeled peptide.
- GC40129Biotin-Amyloid-β (1-40) Peptide (trifluoroacetate salt)Purity: >95.00%
Biotin-amyloid-β (1-40) (biotin-Aβ40) is an affinity probe that allows amyloid-β (1-40) (Aβ40) to be detected or immobilized through interaction with the biotin ligand.
- GC401305-FAM-Amyloid-β (1-42) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
5-FAM-Amyloid-β (1-42) peptide is a fluorescently labeled amyloid-β peptide.
- GC40160Biotin-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
Biotin-amyloid-β (1-28) peptide is a biotinylated peptide.
- GC425055-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt)Purity: >95.00%
5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide.
- GC42798Amyloid-β (1-38) Peptide (trifluoroacetate salt)Purity: >95.00%
Amyloid-β (1-38) (Aβ38) peptide is a fragment of the Aβ42 peptide.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC37984 | β-Amyloid (1-42), rat | 166090-74-0 | >95.00% | |
β-Amyloid (1-42), Ratte, ist ein Peptid mit 42 AminosÄuren, zeigt eine zytotoxische Wirkung auf akute Hippocampus-Schnitte und wird in der Erforschung der Alzheimer-Krankheit verwendet. | ||||
| GC37985 | β-Amyloid 11-22 | 885323-98-8 | >98% | |
β-Amyloid 11-22 ist ein Peptidfragment von β-Amyloid. | ||||
| GC37986 | β-Amyloid 1-17 | 186319-72-2 | >98% | |
β-Amyloid 1-17 ist ein Peptid von β-Amyloid, stabilisiert die Fasern und spielt eine Rolle bei der Aβ-Faserbildung. | ||||
| GC37987 | β-Amyloid 1-20 | 186319-68-6 | >98% | |
β-Amyloid 1-20 besteht aus den Aminosäuren 1 bis 20 des Beta-Amyloid-Proteins. | ||||
| GC37988 | β-Amyloid 12-20 | 134649-29-9 | >98% | |
β-Amyloid 12-20 ist ein Peptidfragment von β-Amyloid. | ||||
| GC37989 | β-Amyloid 13-27 | 148270-13-7 | >98% | |
β-Amyloid 13-27 ist ein Peptid, das aus den Aminosäuren 13 bis 27 des Beta-Amyloid-Proteins besteht. | ||||
| GC37990 | β-Amyloid 1-34 | 186359-65-9 | >98% | |
β-Amyloid 1-34 ist ein β-Amyloid-Peptid, das aus 34 Aminosäuren besteht. | ||||
| GC37991 | β-Amyloid 15-21 | - | >98% | |
| GC37992 | β-Amyloid 18-28 | 112163-49-2 | >98% | |
β-Amyloid 18-28 ist ein Peptidfragment von β-Amyloid. | ||||
| GC37993 | β-Amyloid 1-9 | 147529-30-4 | >98% | |
β-Amyloid 1-9, ein N-terminales Fragment von Beta-Amyloid, besteht aus den Aminosäureresten 1 bis 9. | ||||
| GC37994 | β-Amyloid 22-40 | 1206779-25-0 | >98% | |
β-Amyloid 22-40 ist ein Peptidfragment von β-Amyloid. | ||||
| GC37995 | β-Amyloid 33-40 | 634204-57-2 | >98% | |
β-Amyloid 33-40 ist ein Peptid, das aus den Aminosäuren 33 bis 40 des Beta-Amyloid-Proteins besteht. | ||||
| GC37996 | β-Amyloid 35-42 | 183292-41-3 | >98.00% | |
β-Amyloid 35-42 ist ein Peptid, das aus den Aminosäuren 35 bis 42 des Beta-Amyloid-Proteins besteht. | ||||
| GC37997 | β-Amyloid 4-10 | 477284-32-5 | >98% | |
β-Amyloid 4-10 ist ein Epitop für den polyklonalen Anti-Aβ(1-42)-Antikörper, reduziert die Amyloidablagerung in einem transgenen Mausmodell der Alzheimer-Krankheit. | ||||
| GC37998 | β-Amyloid Protein Precursor 770 135-155 | 315229-44-8 | >98% | |
β-Amyloid Protein Precursor 770 135-155 ist ein Peptid der Isoform des Amyloid-Vorläuferproteins (APP 770). | ||||
| GC39466 | β-Amyloid 15-21 | - | >98% | |
| GC40126 | Amyloid-β Precursor Protein (96-110) Peptide (cyclized) (human) (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β precursor protein (96-110) peptide (cyclized) is a synthetic peptide consisting of amino acids 96-110 of amyloid precursor peptide (APP) that is cyclized via a bridge between the cysteine residues at positions 3 and 10. | ||||
| GC40127 | Amyloid-β (22-35) Peptide (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (Aβ) (22-35) is a 13-residue fragment of Aβ that corresponds to residues 693-705 of the human amyloid precursor protein (APP) full-length sequence. | ||||
| GC40128 | TAMRA-Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
TAMRA-Amyloid-β (1-40) peptide is a fluorescently labeled peptide. | ||||
| GC40129 | Biotin-Amyloid-β (1-40) Peptide (trifluoroacetate salt) | - | >95.00% | |
Biotin-amyloid-β (1-40) (biotin-Aβ40) is an affinity probe that allows amyloid-β (1-40) (Aβ40) to be detected or immobilized through interaction with the biotin ligand. | ||||
| GC40130 | 5-FAM-Amyloid-β (1-42) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
5-FAM-Amyloid-β (1-42) peptide is a fluorescently labeled amyloid-β peptide. | ||||
| GC40160 | Biotin-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
Biotin-amyloid-β (1-28) peptide is a biotinylated peptide. | ||||
| GC42505 | 5-FAM-Amyloid-β (1-28) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
5-FAM-Amyloid-β (1-28) peptide is a fluorescently labeled peptide. | ||||
| GC42798 | Amyloid-β (1-38) Peptide (trifluoroacetate salt) | - | >95.00% | |
Amyloid-β (1-38) (Aβ38) peptide is a fragment of the Aβ42 peptide. | ||||