Hypertension

(R,S)-Carvedilol glucuronide is a racemic mixture of the carvedilol metabolites (R)-carvedilol glucuronide and (S)-carvedilol glucuronide.

15-keto Treprostinil is an impurity found in treprostinil, which is a stable analog of prostaglandin I2 with a longer plasma half-life.

4-hydroxy Nebivolol is a major metabolite of nebivolol.

5-chloro Hydrochlorothiazide is a derivative of hydrochlorothiazide, which is a diuretic and antihypertensive agent that increases renal excretion of sodium, potassium, chloride, and bicarbonate ions by inhibiting tubular reabsorptive mechanisms.

5-methyl-2-HOBA is an isoketal scavenger.

Adrenomedullin (13-52) is a truncated form of adrenomedullin (1-52).

Atrial natriuretic peptide (ANP) is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.

Atrial natriuretic peptide (ANP) (3-28) is a synthetic and truncated form of ANP, which is an endogenous peptide generated by proteolysis of prepro-ANP that is secreted by cardiomyocytes in the heart.

Benazeprilat ist ein oral wirksamer Wirkstoff und der aktive Metabolit von Benazepril, einem Carboxyl-haltigen ACE-Hemmer mit blutdrucksenkender Wirkung.

Beraprost is an analog of prostacyclin in which the unstable enol-ether has been replaced by a benzofuran ether function.

Bopindolol ((±)-Bopindolol)malonat ist ein oral aktiver Antagonist von β-Adrenozeptoren (ARs) mit partieller agonistischer AktivitÄt.

Captoprildisulfid ist ein Metabolit von Captopril mit blutdrucksenkender Wirkung.

Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects.

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2.

Dehydro amlodipine is a potential impurity found in commercial preparations of amlodipine.

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension.

Endothelin-3 is a peptide vasoconstricter and a ligand of the endothelin (ET) receptors ETA and ETB (Kbs = 1.05 and 1.49, respectively).

Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μ ;M, 1.650 μM fÜr ROCK2 bzw. PKA, PKC, PKG. HA-1077 (Hydrochlorid) ist auch ein potenter Ca2+-Kanalantagonist und Vasodilatator.

Bombesin is a peptide, originally isolated from the skin of the European fire-bellied toad, with pressor and sympathoexcitatory activity.

Mabuterol is an agonist of the β2-adrenergic receptor (β2-AR).

N-Desmethyl sildenafil is a major metabolite of sildenafil.

Nebivolol O-β-D-glucuronide is an active metabolite of the β1-adrenergic receptor antagonist nebivolol.

N-Hippuryl-His-Leu (hydrate) is a synthetic substrate for angiotensin-converting enzyme (ACE) that has been used in the in vitro identification of ACE inhibitors.,

Angiotensin II is a hormone that plays an important role in regulating blood pressure.