Sp-ATPαS tetrasodium is a thiophosphonate analogue of ATP. Sp-ATPαS tetrasodium is a competitive antagonist of the human P2Y1 receptor and can inhibit the calcium signal induced by ADP. Sp-ATPαS tetrasodium has higher metabolic stability than ATP. Sp-ATPαS tetrasodium can be used to study the binding mode of metal-nucleotide in enzymatic reactions [1].
References:
[1]. Connolly BA, Eckstein F. S-Methylated nucleoside phosphorothioates as probes of enzyme metal X nucleotide binding sites. Biochemistry. 1982 Nov 23;21(24):6158-67.
[2]. Léon C, et al. The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. 1997 Feb 10;403(1):26-30.
References:
[1]. Connolly BA, Eckstein F. S-Methylated nucleoside phosphorothioates as probes of enzyme metal X nucleotide binding sites. Biochemistry. 1982 Nov 23;21(24):6158-67.
[2]. Léon C, et al. The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. FEBS Lett. 1997 Feb 10;403(1):26-30.