DMPE-PEG2000-N3 (DMPE-PEG2000-Azide) is a conjugate composed of DMPE, PEG chains, and terminal azido groups (-N3). DMPE-PEG2000-Azide is a click chemistry reagent used for the targeted modification of liposomes/nanoparticles.
In Vitro, DMPE-PEG-Azide is used as a core component in the preparation of liposomes or lipid nanoparticles (LNPs) to encapsulate drugs or genes. Containing the Azide group, DMPE-PEG-Azide can undergo a copper-catalyzed azido-alkynylene cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo a ring-strain-driven alkynylene-azido cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.
In Vitro, DMPE-PEG-Azide is used as a core component in the preparation of liposomes or lipid nanoparticles (LNPs) to encapsulate drugs or genes. Containing the Azide group, DMPE-PEG-Azide can undergo a copper-catalyzed azido-alkynylene cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo a ring-strain-driven alkynylene-azido cycloaddition reaction (SPAAC) with molecules containing DBCO or BCN groups.