DSPE-PEG 2000

DSPE-PEG 2000 is a PEG liposome that can be used to form micelles as nanoparticles for drug delivery^[1]. Mixed micelles (DSPE-PEG 2000/DSPE-PEG 3400-2C5/PHIS-PEG 2000) can enhance tumor cell-specific internalization and trigger rapid drug release, thereby improving anticancer drug efficacy^[2]. DSPE-PEG 2000 micellar formulations can greatly increase the solubility and circulation time of rapamycin, while also greatly reducing nonspecific toxicity^[3]. DSPE-PEG 2000 exists in equilibrium between monomeric, micellar, and bovine serum albumin (BSA)-bound states, and this equilibrium shifts toward the BSA-bound state when the temperature increases from 20 to 37°C^[4].

References:
[1] Vijayakumar M R, Kosuru R, Vuddanda P R, et al. Trans resveratrol loaded DSPE PEG 2000 coated liposomes: an evidence for prolonged systemic circulation and passive brain targeting[J]. Journal of drug delivery science and technology, 2016, 33: 125-135.
[2] Wu H, Zhu L, Torchilin V P. pH-sensitive poly (histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery[J]. Biomaterials, 2013, 34(4): 1213-1222.
[3] Remsberg C M, Zhao Y, Takemoto J K, et al. Pharmacokinetic evaluation of a DSPE-PEG2000 micellar formulation of ridaforolimus in rat[J]. Pharmaceutics, 2012, 5(1): 81-93.
[4] Kastantin M, Missirlis D, Black M, et al. Thermodynamic and kinetic stability of DSPE-PEG (2000) micelles in the presence of bovine serum albumin[J]. The Journal of Physical Chemistry B, 2010, 114(39): 12632-12640.