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DSPE-PEG2000-KTP

Catalog No.GC79701 Copy One-Click Copy Product Info

DSPE-PEG2000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP.

Products are for research use only. Not for human use. We do not sell to patients.

DSPE-PEG2000-KTP Chemical Structure

Size Price Stock Qty
5mg
$763.00
In stock

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Sample solution is provided at 25 µL, 10mM.



Description of DSPE-PEG2000-KTP

DSPE-PEG2000-KTP is a PEG compound which composed of DSPE and a Kidney-targeting peptide KTP. KTP can interact with specific proteins on the surface of renal tubular epithelial cells or exhibit higher affinity in the specific renal microenvironment, tending to aggregate or be internalized within the renal tubular epithelium. DSPE-PEG2000-KTP can actively guide carriers such as nanomedicines, liposomes, and microspheres to the kidney [1].

In Vitro, Lipids used to prepare nanoparticles are a class of amphiphilic biomolecules that combine structural diversity, biocompatibility, and functional tunability. As the core framework of nanodelivery systems, they not only form lipid bilayers or solid matrices through self-assembly to encapsulate lipophilic or hydrophilic drugs, but can also be further subdivided according to formulation requirements into structural lipids (such as phospholipids and triglycerides), functional lipids (such as ionizable cationic lipids used for nucleic acid condensation and endosome escape), and sterically stable lipids (such as PEGylated lipids).

References:
[1]. Xuan C, et al. Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization. Adv Sci (Weinh). 2025 Jul;12(25):e2414587.

Chemical Properties of DSPE-PEG2000-KTP

Cas No. SDF
Formula M.Wt
Solubility Storage Store at -20°C
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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**When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / CoA (available online).

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In vivo Formulation Calculator (Clear solution) of DSPE-PEG2000-KTP

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for DSPE-PEG2000-KTP

Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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