DSPE-PEG2000-OH is an absorption enhancer. DSPE-PEG2000-OH reduces the expression levels of ZO-1 and Occludin. DSPE-PEG2000-OH enhances the pulmonary absorption of poorly absorbable macromolecules via the paracellular pathway without altering pulmonary membrane fluidity [1].
In Vivo, DSPE-PEG-OH (0.1-2.0% (w/v); intratracheal administration; single dose) significantly enhances the pulmonary absorption of poorly absorbable macromolecules in rats, with a maximum enhancement fold of 4.5-fold for FD10 at the dose of 1.0% (w/v)[1]. DSPE-PEG-OH (0.1-1.0% (w/v); intratracheal administration; single dose; 1.0% (w/v); intratracheal administration; once weekly; for 2 consecutive weeks) does not induce significant local pulmonary membrane damage in brown rats (rats) at doses up to 1.0% (w/v), whether administered as a single intratracheal dose or once weekly for 2 consecutive weeks[1].
In Vitro, DSPE-PEG2000-OH (1% (w/v); 20 min) does not alter the fluidity of isolated rat lung membrane vesicles, as measured by fluorescence polarization using DPH and TMA-DPH probes[1].
References:
[1]. Gao Y, et al. DSPE-PEG polymers for improving pulmonary absorption of poorly absorbed macromolecules in rats and relative mechanism. Drug Dev Ind Pharm. 2021;47(2):337-346.
In Vivo, DSPE-PEG-OH (0.1-2.0% (w/v); intratracheal administration; single dose) significantly enhances the pulmonary absorption of poorly absorbable macromolecules in rats, with a maximum enhancement fold of 4.5-fold for FD10 at the dose of 1.0% (w/v)[1]. DSPE-PEG-OH (0.1-1.0% (w/v); intratracheal administration; single dose; 1.0% (w/v); intratracheal administration; once weekly; for 2 consecutive weeks) does not induce significant local pulmonary membrane damage in brown rats (rats) at doses up to 1.0% (w/v), whether administered as a single intratracheal dose or once weekly for 2 consecutive weeks[1].
In Vitro, DSPE-PEG2000-OH (1% (w/v); 20 min) does not alter the fluidity of isolated rat lung membrane vesicles, as measured by fluorescence polarization using DPH and TMA-DPH probes[1].
References:
[1]. Gao Y, et al. DSPE-PEG polymers for improving pulmonary absorption of poorly absorbed macromolecules in rats and relative mechanism. Drug Dev Ind Pharm. 2021;47(2):337-346.