GLPBio

EDTA-AM

Catalog No.: GC76174Purity:>98.00%Synonyms: EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
COASDSData Sheet
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA .

Products are for research use only. Not for human use. We do not sell to patients.

EDTA-AM
Cas No.: 162303-59-5
5 mgIn Stock
$113.00
1
10 mgIn Stock
$180.00
1
25 mgIn Stock
$360.00
1
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Description

EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA . Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation[1][2].

References:
[1]. Watkins CS, et.al. Effects on K+ currents in rat cerebellar granule neurones of a membrane-permeable analogue of the calcium chelator BAPTA. Br J Pharmacol. 1996 Aug;118(7):1772-8.
[2]. Maeshima K, et.al. A Transient Rise in Free Mg2+Ions Released from ATP-Mg Hydrolysis Contributes to Mitotic Chromosome Condensation. Curr Biol. 2018 Feb 5;28(3):444-451.e6.

Product Documents

Purity:>98.00%Appearance:A liquid
COASDSData Sheet

Chemical Properties

CAS No.
162303-59-5
Synonyms
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
Molecular Formula
C22H32N2O16
Molecular Weight
580.49
Solubility
DMSO: 100 mg/mL (172.27 mM; Need ultrasonic)
Storage
-20°C, protect from light, stored under nitrogen
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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