FAPI-800CW is a near-infrared (NIR) fluorescent-labeled fibroblast activation protein ( FAP ) inhibitor. FAPI-800CW shows specific uptake in inflamed paws in collagen-induced arthritis (CIA) model mice. FAPI-800CW can be used for in vivo molecular imaging of FAP expression in inflammatory diseases such as rheumatoid arthritis (RA) to monitor joint inflammation and disease activity [1].
In Vivo, FAPI-800CW (1-2 nmol, i.v., single dose) shows significantly higher mean fluorescence intensity (MFI) in inflamed paws than in healthy paws of collagen-induced arthritis (CIA) model DBA/1J mice[1].
References:
[1]. Narain R, et al. Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein. Npj Imaging. 2024 Aug 2;2(1):24.
In Vivo, FAPI-800CW (1-2 nmol, i.v., single dose) shows significantly higher mean fluorescence intensity (MFI) in inflamed paws than in healthy paws of collagen-induced arthritis (CIA) model DBA/1J mice[1].
References:
[1]. Narain R, et al. Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein. Npj Imaging. 2024 Aug 2;2(1):24.