18-Azido-stearic acid is a click chemistry reagent containing an azide group, which can be used as a hydrophobic bioconjugation linker (using N-Myristoyltransferase) that can be further modified at the azido-position using Click-chemistry [2]. 18-Azido-stearic acid can be used to prepare functionalized glycerol/diacid dendrimers for modifying and linking signaling peptides or controlling charge patterns, thereby enabling selective targeting of encapsulated drugs or delivery to specific biological sites [2].
References:
[1] Ejendal K F K, Fraseur J G, Kinzer-Ursem T L. Protein labeling and bioconjugation using N-Myristoyltransferase[M]//Bioconjugation: Methods and Protocols. New York, NY: Springer New York, 2019: 149-165.
[2] Zerkowski J A, Nunez A, Solaiman D K Y. Selectively functionalized glycerol/diacid dendrimers via click chemistry of azido fatty acids[J]. Journal of the American Oil Chemists' Society, 2011, 88(3): 403-413.