(1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC 50 of 116 nM in HEK293 cells.
In Vitro, (1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. (1R,2R)-2-PCCA is approximately 5-fold more potent than (1S,2S)-2-PCCA[1].
References:
[1]. Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.
In Vitro, (1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. (1R,2R)-2-PCCA is approximately 5-fold more potent than (1S,2S)-2-PCCA[1].
References:
[1]. Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.