4-Piperidyl N-(2-biphenyl)carbamate (compound MA) is a competitive muscarinic acetylcholine receptor ( mAChR ) antagonist. 4-Piperidyl N-(2-biphenyl)carbamate exhibits higher affinity for M 2 and M 3 mAChR than β 2 AR (M 2 pK i = 7.33; M 3 pK i = 7.51; β 2 AR pK i = 4.94) [1].
References:
[1]. Steinfeld T, et al. THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol. 2011 Mar;79(3):389-99.
References:
[1]. Steinfeld T, et al. THRX-198321 is a bifunctional muscarinic receptor antagonist and beta2-adrenoceptor agonist (MABA) that binds in a bimodal and multivalent manner. Mol Pharmacol. 2011 Mar;79(3):389-99.