7-O-(Amino-PEG4)-paclitaxel |
| Catalog No.GC60033 |
Le 7-O-(Amino-PEG4)-paclitaxel est un lieur PROTAC À base de PEG qui peut être utilisé dans la synthèse des PROTAC.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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7-O-(Amino-PEG4)-paclitaxel is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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