AMPA receptor modulator-10 (Compound 9a) is an orally active AMPA receptor ( AMPAR ) positive allosteric modulator. AMPA receptor modulator-10 exhibits potent activity ( pEC 50 = 5.0) on the GluA2 subtype of AMPAR, significantly enhancing glutamate-induced calcium influx and current responses. AMPA receptor modulator-10 can reverse the memory impairment induced by Scopolamine and enhance cognitive function. AMPA receptor modulator-10 can be used for the research of neurological disease, such as schizophrenia [1].
References:
[1]. Ward SE, et al. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. J Med Chem. 2011 Jan 13;54(1):78-94.
References:
[1]. Ward SE, et al. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. J Med Chem. 2011 Jan 13;54(1):78-94.