Anti-CD71/TfR1 Antibody (JR-141 antibody (uncoupled from iduronate 2-sulfatase)) is a humanized anti-human transferrin receptor ( CD71/TfR1 ) antibody. Anti-CD71/TfR1 Antibody is the antibody part of the fusion protein Pabinafusp alfa. The recommend isotype control of Anti-CD71/TfR1 Antibody: Human IgG1 kappa, Isotype Control [1] [2].
In Vitro, Pabinafusp alfa is a blood-brain barrier-penetrating fusion protein that inhibits the deposition of heparan sulfate in the central nervous system of mice with mucopolysaccharidosis II, improves learning ability in the mice, and prevents neuronal damage in the central nervous system[1][2].
References:
[1]. Yamamoto R, et al. Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II. Mol Genet Metab Rep. 2021 Apr 18;27:100758.
[2]. Sonoda H, et al. A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II. Mol Ther. 2018;26(5):1366-1374.
In Vitro, Pabinafusp alfa is a blood-brain barrier-penetrating fusion protein that inhibits the deposition of heparan sulfate in the central nervous system of mice with mucopolysaccharidosis II, improves learning ability in the mice, and prevents neuronal damage in the central nervous system[1][2].
References:
[1]. Yamamoto R, et al. Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II. Mol Genet Metab Rep. 2021 Apr 18;27:100758.
[2]. Sonoda H, et al. A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II. Mol Ther. 2018;26(5):1366-1374.