Aposcopolamine is a tropane alkaloid that has been found in D. ferox and is an active metabolite of the muscarinic antagonist scopolamine.1,2 It is selective for muscarinic acetylcholine receptors (mAChRs) over nicotinic AChRs (nAChRs; IC50s = 0.0192 and 188 µM, respectively).3
1.Vitale, A.A., Acher , A., and Pomilio, A.B.Alkaloids of Datura ferox from ArgentinaJ. Ethnaopharmacol.49(2)81-89(1995) 2.Chen, H., Chen, Y., Du, P., et al.Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of in vivo and in vitro metabolites of scopolamine in ratsJ. Chromatogr. Sci.46(1)74-80(2008) 3.Schmeller, T., Sporer, F., Sauerwein, M., et al.Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptorsPharmazie50(7)493-495(1995)