ARUK2001607 is a selective phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ)inhibitor with a Kd of 7.1 nM. ARUK2001607 shows high selectivity over other >150 kinases.
In Vivo Mouse Pharmacokinetics Parameters for Selected ARUK2001607 (15) (5 mg/kg; ip Administration)[1]
References:
[1]. Timot P C Rooney, et al. The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules. J Med Chem. 2022 Dec 14.