CMPF-d5 contains five deuterium atoms at the 2, 2', 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of CMPF by GC- or LC-mass spectrometry. Furan fatty acids are unique, naturally occurring lipids that are found in significant amounts in dietary phospholipids, such as in salmon roe.1 CMPF is an endogenous metabolite of furan fatty acids in humans. CMPF is highly albumin-bound and accumulates in the serum of uremic patients to concentrations in excess of 0.2 mM. Its primary effect is to inhibit cellular transport and subsequent deiodination of thyroxine (T4).2,3 CMPF is tightly bound to albumin but only moderately inhibits T4 binding in a direct manner (10-14% at 0.3 mM). However, CMPF effectively displaces competitive T4 binding molecules from albumin, such as acidic drugs and free fatty acids.3 Therefore, CMPF may indirectly influence T4 binding to albumin by increasing the serum concentration of competitive binding molecules, particularly free fatty acids such as oleic acid.3
1.Ishii, K., Okajima, H., Okada, Y., et al.Studies on furan fatty acids of salmon roe phospholipidsJournal of Biochemistry103(5)836-839(1988)
2.Lim, C.F., Bernard, B.F., De Jong, M., et al.A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremiaJournal of Clinical Endocrinology and Metabolism76(2)318-324(1993)
3.Lim, C.F., Stockigt, J.R., Curtis, A.J., et al.A naturally occuring furan fatty acid enhances drug inhibition of thyroxine binding in serumMetabolism42(11)1468-1474(1993)
