COTC (Synonyms: 2-Crotonyloxymethyl-(4R,5R,6R)-4,5,6-trihydroxycyclohex-2-enone) |
| Catalog No.GC52018 |
A bacterial metabolite with anticancer activity
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Cas No.: 57449-30-6
Sample solution is provided at 25 µL, 10mM.
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COTC is a bacterial metabolite that has been found in S. griseosporeus and has anticancer activity.1 It inhibits glyoxalase in the presence of glutathione (GSH) in a concentration- and time-dependent manner. COTC inhibits the proliferation of HeLa cells (IC50 = 18 µg/ml), as well as reduces tumor growth and improves survival in an Ehrlich murine spontaneous adenocarcinoma model.
1.Takeuchi, T., Chimura, H., Hamada, M., et al.A glyoxalase I inhibitor of a new structural type produced by StreptomycesJ. Antibiot. (Tokyo)28(1)737-742(1975)
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